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Clomid (clomiphene) is an oral medication that can be used to stimulate ovulation.

How does it work?

The drug works by blocking estrogen receptors at the hypothalamus, which is an important “hormonal control center” for the body.


The drug is used to treat:

  • ovulation induction with anovulatory ovarian dysfunction and related infertility;
  • violation of ovulation with hypothalamic insufficiency;
  • secondary amenorrhea of various origins;
  • oligomenorrhea;
  • dysfunctional uterine bleeding;
  • non-tumor galactorrhea;
  • Stein-Leventhal syndrome;
  • Chiari-Frommel syndrome;
  • oligospermia.

How to take Clomid?

Women take these tablets orally – 50 mg starting from the 5th and 10th day of the period. In the absence of ovulation, treatment is repeated in the next cycle with an increase in dosage to 100 mg. If necessary, the third course of treatment is carried out in the maximum dosage. If ovulation does not occur, then it is considered inappropriate to conduct more than three courses of therapy.

After the use of Clomiphene, it is recommended to take drugs containing progesterone. This is required in order to prevent corpus luteum failure.

Men take a 50 mg tablet 1 or 2 times a day for 6 weeks under constant monitoring of sperm.


Do not take Clomid if you have any of the following conditions/diseases:

  • impaired liver function;
  • ovarian cyst;
  • genital malignancies;
  • primary hypofunction of the pituitary gland;
  • uterine bleeding of unknown origin;
  • pregnancy;
  • lactation (breastfeeding);
  • hypersensitivity to the components of the drug.

Side effects

Clomid rarely causes side effects. They are usually caused by an overdose:

  • Nervous system: dizziness, headache; depression, fatigue, anxiety, and insomnia;
  • Digestive system: nausea, periodic vomiting, pain in the epigastric region;
  • Endocrine system: hot flashes similar to the symptoms of menopause, cystic ovarian enlargement (especially with Stein-Leventhal syndrome), dysmenorrhea;
  • Dermatological reactions: reversible hair loss;
  • Metabolism: an increase in body weight;
  • Allergic reactions: urticaria, allergic dermatitis;
  • Other: heat sensation and visual impairment, chest pain, increased urination and polyuria, pain in the testicles (in men).


Symptoms: nausea, vomiting, hot flashes, visual disturbances, abdominal pain.

Treatment: symptomatic therapy.

Interaction with other drugs

The drug is compatible with gonadotropin hormones.

Special instructions

Before treatment, a woman should undergo a thorough gynecological examination. Treatment begins when the total urinary gonadotropin level is normal or below a normal level, the state of the ovaries on palpation is normal, and the functions of the thyroid gland and adrenal glands are well coordinated. In case of ovulation failure, all other possible forms of infertility should be excluded or cured before treatment is started.

If ovarian enlargement or cystic changes occur while taking the drug, treatment should be discontinued until the ovary size returns to normal. Further treatment can be continued, but the drug should be prescribed in lower doses or the treatment period should be reduced. During therapy, the condition of the ovaries should be monitored.

Clomid is used only with the constant supervision of a gynecologist.

As a result of treatment, multiple pregnancy may occur.

During treatment, it is recommended to monitor liver function.

Since temporary visual impairment occurs at the beginning of treatment, it is not recommended to engage in driving vehicles and other potentially dangerous activities.